3 Antioxidants for Longevity

Antioxidants are well-known for their role in protecting cells from oxidative stress, and they play an important role in longevity. Along with a healthy diet, lifestyle choices and physical activity, antioxidants contribute to a sharp memory, healthy mood, and whole-body wellness. Luckily for us, antioxidants come in a variety of forms.

Support healthy cellular aging

Ergothioneine is an amino acid with powerful free-radical quenching and cell-protecting properties. Your body has a highly specific mechanism to transport ergothioneine into your cells, suggesting it is crucial for overall health. But your body can’t produce it, so you must get it through your diet (mushrooms, anyone?), or through supplements that contain L-ergothioneine.

Ergothioneine supports healthy cellular aging by delaying telomere shortening due to oxidative stress.* Your telomeres are like protective caps at the end of your chromosomes. As time goes by, these telomeres shorten naturally, but studies have shown L-ergothioneine has a protective effect on telomere length.* It also supports cognitive, vision and heart health.*

Target senescent cells

Found in fruits and vegetables, fisetin is an antioxidant that encourages the natural clearing of senescent cells that have outlived their usefulness. This allows healthy cells to flourish. But fisetin is hard for the body to absorb. So scientists have optimized fisetin with fenugreek fibers to be up to 25 times more bioavailable, a form that gives you maximum benefits.

Besides supporting longevity, fisetin supports brain health and helps protect brain function.* It also supports healthy glucose metabolism, which helps protect your eye and kidney health.*

Protect your brain at the cellular level

Vitamin B12 (also called cobalamin) is a water-soluble vitamin that plays a vital role in the health of your nervous system, red blood cells, and even your DNA (by helping protect delicate parts of your chromosomes).* Because it comes mainly from animal sources, many people don’t get enough B12 from their diet alone.

There are two neurologically active forms of this crucial vitamin— adenosylcobalamin and methylcobalamin. Adenosylcobalamin really shines in studies that demonstrate its ability to protect brain cells and support dopamine levels.* It is also active in the mitochondria to support nerve cell energy.* Combining adenosylcobalamin and methylcobalamin makes it easier for your body to absorb and access this B12.*

References

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2. National Human Genome Research Institute. Telomere. NIH. Accessed 4/8/2022, https://www.genome.gov/genetics-glossary/Telomere#:~:text=A%20telomere%20is%20the%20end,divides%2C%20the%20telomeres%20become%20shorter

3. Cheah IK, Halliwell B. Ergothioneine, recent developments. Redox Biology. 2021:101868. doi:10.1016/j.redox.2021.101868

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5. Samuel P, Tsapekos M, de Pedro N, Liu AG, Casey Lippmeier J, Chen S. Ergothioneine Mitigates Telomere Shortening under Oxidative Stress Conditions. J Diet Suppl. Dec 7 2020:1-14. doi:10.1080/19390211.2020.1854919

6. Beelman RB, Kalaras MD, Phillips AT, Richie JP, Jr. Is ergothioneine a 'longevity vitamin' limited in the American diet? J Nutr Sci. 2020;9:e52. doi:10.1017/jns.2020.44

7. Zhang L, Pitcher LE, Prahalad V, Niedernhofer LJ, Robbins PD. Targeting cellular senescence with senotherapeutics: senolytics and senomorphics. The FEBS journal. n/a(n/a)doi: https://doi.org/10.1111/febs.16350

8. Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. Sep 29 2018;doi:10.1016/j.ebiom.2018.09.015

9. Wang L, Tu YC, Lian TW, Hung JT, Yen JH, Wu MJ. Distinctive antioxidant and antiinflammatory effects of flavonols. J Agric Food Chem. Dec 27 2006;54(26):9798-804. doi:10.1021/jf0620719

10. Jia S, Xu X, Zhou S, Chen Y, Ding G, Cao L. Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum stress- and mitochondrial stress-dependent pathways. Cell death & disease. 2019;10(2):142-142. doi:10.1038/s41419-019-1366-y

11. Suh Y, Afaq F, Johnson JJ, Mukhtar H. A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways. Carcinogenesis. Feb 2009;30(2):300-7. doi:10.1093/carcin/bgn269

12. Khan N, Syed DN, Ahmad N, Mukhtar H. Fisetin: a dietary antioxidant for health promotion. Antioxid Redox Signal. Jul 10 2013;19(2):151-62. doi:10.1089/ars.2012.4901

13. Zhu Y, Doornebal EJ, Pirtskhalava T, et al. New agents that target senescent cells: the flavone, fisetin, and the BCL-X(L) inhibitors, A1331852 and A1155463. Aging (Albany NY). Mar 8 2017;9(3):955-963. doi:10.18632/aging.101202

14. Schaffner A, Li X, Gomez-Llorente Y, et al. Vitamin B(12) modulates Parkinson's disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection. Cell Res, Apr 2019;29(4):313-329. doi:10.1038/s41422-019-0153-8

15. Paul C, Brady DM. Comparative Bioavailability and Utilization of Particular Forms of B(12) Supplements With Potential to Mitigate B(12)-related Genetic Polymorphisms. Integr Med (Encinitas). Feb 2017;16(1):42-49.

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.