Pure Encapsulations, Choline (bitrate) 275 mg, 100 Capsules

• Provides 275 mg choline per capsule

• Highly bioavailable and researched choline bitartrate form

• Promotes optimal cellular function as a key building block for methylation

• Supports cognitive function as a component of phospholipids and acetylcholine

• Supports healthy hepatic fat metabolism

Key vitamin to support healthy methylation, cell function and neurotransmission

The Science: Choline is required for the synthesis of phospholipids and acetylcholine, a neurotransmitter involved in attention, learning and memory.1‡

Certain genetic variations in MTHFD1 and PEMT, enzymes that play critical roles in methylation and phosphatidylcholine synthesis, respectively, have been associated with increased dietary choline needs.

Since the de novo synthesis of phosphatidylcholine requires the estrogen-inducible PEMT enzyme, women with low estrogen levels and/or certain SNPs in the PEMT gene have increased choline needs.5 Postmenopausal women with lower estrogen have higher dietary choline requirements because of reduced PEMT function.

Choline requirements also increase during pregnancy.

One clinical trial showed that women who consumed 480 mg of choline daily during pregnancy had offspring with faster processing speed than those who did not.8‡ A randomized, double-blind, placebo-controlled trial suggests that higher intake of choline also promotes healthy hepatic fat metabolism.